Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection
Identifieur interne : 001A08 ( Main/Exploration ); précédent : 001A07; suivant : 001A09Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection
Auteurs : Dana M. Grzybicki [États-Unis] ; Kyubum Kwack [États-Unis] ; Stanley Perlman [États-Unis] ; Sean P. Murphy [États-Unis]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1997.
English descriptors
- Teeft :
- Acute infection, Acute meningoencephalitis, Astrocyte, Brain parenchyma, Brain sections, Cellular distribution, Cellular localization, Cord sections, Cytokine, Demyelinated, Demyelinating, Demyelination, Encephalitis, Encephalomyelitis, Endogenous cells, Gfap, Glial cells, Grzybicki, Hindlimb, Hindlimb paralysis, Hybridization, Hybridization analysis, Immunohistochemical, Immunohistochemical staining, Immunol, Inducible, Inducible nitric oxide synthase, Infection, Inflammatory, Inflammatory cells, Iowa city, Iowa college, Lesion, Macrophage, Microglia, Mouse, Mouse hepatitis virus, Mrna, Murine, Neuroimmunology, Neuron, Nitric, Nitric oxide, Nitric oxide synthase, Olfactory, Olfactory bulb, Oxide, Pathological changes, Perlman, Persistent infection, Polyclonal antibody, Positive cells, Primary antibody, Septal area, Silver grains, Spinal, Spinal cord, Spinal cords, Stohlman, Synthase, Time course, Time point, Ventromedial brain, Viral, Viral antigen, Viral clearance, Virol, Weiner, White matter.
Abstract
Abstract: Intranasal inoculation with mouse hepatitis virus strain JHM (MHV-JHM) results in acute meningoencephalitis. We found NOS II mRNA expression in brains of acutely infected animals on days 5 through 7 after infection. In situ hybridization and immunohistochemistry demonstrated NOS II message and protein in infiltrating macrophages. Persistent infection with MHV-JHM results in chronic demyelinating encephalomyelitis. NOS II mRNA was detected in persistently infected spinal cords. In situ hybridization and immunohistochemistry showed expression of NOS II in astrocytes in and around demyelinated lesions. These results suggest the role of NO release in acute versus persistent infection with this virus, and its contribution to the resulting pathology, may be different.
Url:
DOI: 10.1016/S0165-5728(96)00159-2
Affiliations:
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Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">73</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="15">15</biblScope><biblScope unit="page" to="27">27</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute infection</term><term>Acute meningoencephalitis</term><term>Astrocyte</term><term>Brain parenchyma</term><term>Brain sections</term><term>Cellular distribution</term><term>Cellular localization</term><term>Cord sections</term><term>Cytokine</term><term>Demyelinated</term><term>Demyelinating</term><term>Demyelination</term><term>Encephalitis</term><term>Encephalomyelitis</term><term>Endogenous cells</term><term>Gfap</term><term>Glial cells</term><term>Grzybicki</term><term>Hindlimb</term><term>Hindlimb paralysis</term><term>Hybridization</term><term>Hybridization analysis</term><term>Immunohistochemical</term><term>Immunohistochemical staining</term><term>Immunol</term><term>Inducible</term><term>Inducible nitric oxide synthase</term><term>Infection</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Iowa city</term><term>Iowa college</term><term>Lesion</term><term>Macrophage</term><term>Microglia</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Mrna</term><term>Murine</term><term>Neuroimmunology</term><term>Neuron</term><term>Nitric</term><term>Nitric oxide</term><term>Nitric oxide synthase</term><term>Olfactory</term><term>Olfactory bulb</term><term>Oxide</term><term>Pathological changes</term><term>Perlman</term><term>Persistent infection</term><term>Polyclonal antibody</term><term>Positive cells</term><term>Primary antibody</term><term>Septal area</term><term>Silver grains</term><term>Spinal</term><term>Spinal cord</term><term>Spinal cords</term><term>Stohlman</term><term>Synthase</term><term>Time course</term><term>Time point</term><term>Ventromedial brain</term><term>Viral</term><term>Viral antigen</term><term>Viral clearance</term><term>Virol</term><term>Weiner</term><term>White matter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Intranasal inoculation with mouse hepatitis virus strain JHM (MHV-JHM) results in acute meningoencephalitis. We found NOS II mRNA expression in brains of acutely infected animals on days 5 through 7 after infection. In situ hybridization and immunohistochemistry demonstrated NOS II message and protein in infiltrating macrophages. Persistent infection with MHV-JHM results in chronic demyelinating encephalomyelitis. NOS II mRNA was detected in persistently infected spinal cords. In situ hybridization and immunohistochemistry showed expression of NOS II in astrocytes in and around demyelinated lesions. These results suggest the role of NO release in acute versus persistent infection with this virus, and its contribution to the resulting pathology, may be different.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Grzybicki, Dana M" sort="Grzybicki, Dana M" uniqKey="Grzybicki D" first="Dana M" last="Grzybicki">Dana M. Grzybicki</name></region><name sortKey="Kwack, Kyubum" sort="Kwack, Kyubum" uniqKey="Kwack K" first="Kyubum" last="Kwack">Kyubum Kwack</name><name sortKey="Murphy, Sean P" sort="Murphy, Sean P" uniqKey="Murphy S" first="Sean P" last="Murphy">Sean P. Murphy</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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